Evaluation of Tissue Regeneration as Support in Translative Research

In Preclinical, Toxicology by Berengere

Due to ethical and moral considerations, translational research relies on the use of test models to approximate human wound healing in order to predict therapeutic outcomes. Efficient translation of basic wound healing research findings to wound care improvements is based on wide investigations in preclinical studies with a clear understanding of the strengths and limitations of models utilized.

Histological assessment of experimental wounds throughout tissue regeneration provides information concerning factors affecting healing. Under standardized conditions, objective and quantitative evaluation of selected parameters allows for a more precise and reproducible assessment of histological changes. Since new generation sophisticated treatments have shown similar performances, a novel approach is proposed here with the analysis of tissue growth metrics by histomorphometry. The tissue ingrowth measurements include cell ingrowth rate, total collagen content and quality of collagen matrix through ratio collagen I/collagen III.

This innovative technical approach permits a better discrimination and selection of therapeutic candidates in screening studies.

If you would like to learn more about this approach, the author, NAMSA pathogist Bérengère Wryzkowski, will be presenting at the European Wound Management Association Conference during the e-poster session.  You can meet with Dr. Wryzkowski and other NAMSA representatives to discuss histopathology, preclinical, clinical and consulting needs that you may have with our wound product.  If you would like to schedule a meeting, please contact us.

If you would like more information on NAMSA’s wound management experience, please visit our service page.