Ophthalmology - Intraocular Lenses

Note: This list provides an overview—our technical specialists and scientists will partner with you to develop specific, cost-effective test programs that minimize your time to market.

Research and Development Support

Materials Characterization
- Thorough material characterization as required for implants
- Monomer assay as appropriate

Non-Clinical Testing

Biocompatibility

Cytotoxicity using multiple methods (MEM, agar overlay and extract, and colony assay)
Sensitization study using aqueous and non-aqueous extracts
Acute systemic toxicity using aqueous and non-aqueous extracts
Intracutaneous irritation using aqueous and non-aqueous extracts
Series of genotoxicity assays (generally three)
Muscle implant tests at various intervals (e.g., 4, 12, 26 weeks)
Intraocular implant study (minimum 6 months)

Additional Testing

Optional Tests to Consider

YAG laser lens exposure
Scanning electron microscopy of explanted lenses

Physical Testing

Physical Properties to Evaluate

Color and light transmittance
Refractive index
Water content
Wetting angle
Oxygen permeability