Ophthalmology - Contact Lenses

Note: This list provides an overview—NAMSA technical specialists and scientists will partner with you to develop specific, cost-effective test programs that minimize your time to market.

Research and Development Support

Materials Characterization
- Thorough chemical characterization of all critical components
- Monomer assay as appropriate

Non-Clinical Testing

Biocompatibility (this = expandable link)

Cytotoxicity by the MEM elution or agar overlay method
Sensitization or allergenicity study using aqueous and non-aqueous extracts
Ocular irritation screen using aqueous and non-aqueous extracts
Acute systemic toxicity using aqueous and non-aqueous extracts
Series of genotoxicity assays (generally three)
Two-week implant test in muscle or subcutaneous tissue, with histopathology
Three-week lens wear study

Additional Testing

Corneal lactic acid determination
Preservative uptake and release evaluation
Mutagenicity (genotoxicity) assays